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Type 1 diabetes results from autoimmune destruction of insulin-producing β cells in the pancreas. Genetic and environmental factors act together to precipitate the disease. The excess mortality associated with the complications of type 1 diabetes and the increasing incidence of childhood type 1 diabetes emphasize the importance of therapeutic strategies to prevent this chronic disorder. In the past 20 years, multiple clinical trials have attempted to find prevention approaches for type 1 diabetes in children before its occurrence (primary prevention), during the initial stage of autoimmune development (secondary prevention), or even after diagnosis of diabetes (tertiary prevention).